(global-set-key (kbd "C-1") 'delete-other-windows)
(global-set-key (kbd "C-2") 'split-window-below)
(global-set-key (kbd "C-3") 'split-window-right)
(global-set-key (kbd "C-0") 'delete-window)
It gives the window manipulating commands I use the most nicer key bindings; just by keeping the Ctrl key pressed and typing away (crazily) on the keys 2 and 3 you can create master pieces of window configurations :)
I could do this since I realized I seldom or never use these shortcuts to enter a numeric argument. If I need to, I can use a slightly longer key sequence like C-u 1 or M-1 which I have kept (for now...).